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1-HOB

Prevent racemization and Accelerate peptide Synthesis

Otsuka Chemical offers triazole derivatives “1-HOB” as a coupling reagent for Protein and Peptide Synthesis. It is effective for acceleration of peptide synthesis and prevention of racemization in the formation of amide bond.

Advantages

It can be used as esterification reagent. It is especially effective for racemization prevention in the peptide synthesis.

Coupling Agent for Protein and Peptide Synthesis

  • 1-HOB(HOBt)
  • HBTU
  • TBTU

General Properties

 
1-HOB (HOBt)
HBTU
TBTU
Chemical formula
1-Hydroxybenzotriazole
monohydrate
O-(1H-Benzotriazol-1-yl)-
N,N,N’,N’-tetramethyl-uronium
hexafl uorophoshate
O-(1H-Benzotriazol-1-yl)-
N,N,N’,N’-tetramethyl-uronium
tetrafl uoroborate
Cas No.
80029-43-2 94790-37-1 125700-67-6
Melting point (°C)
157 ~ 160 200 205