Technology-development-laboratory

Process development

The Technology Development Laboratory is working to support stable production, to improve product appeal and to develop processes for future products. It uses process development technologies that it has cultivated over many years to create a wide variety of products such as hydrazine derivatives, beta-lactam compounds and other fine chemicals.

Process development

Features of the research institute

  1. From initial studies to the opening of plants

    From initial studies to the opening of plants

    Its scope of research includes the exploration of formulae for projects in the early stages of development, prototyping and the opening plants for many different kinds of compounds. We develop chemicals independently and we are commissioned to produce chemicals. The unique technologies possessed by this laboratory include technologies for handling hydrazine, derivatization technologies, technologies for beta-lactam intermediates and technologies for the customized synthesis of APIs.

Development case studies

  • Technologies for derivatizing hydrazine

    Technologies for derivatizing hydrazine

    We⁠⁠⁠⁠⁠⁠ became the first in Japan to successfully industrialize hydrazine monohydrate and other hydrazine derivatives. Additionally, the laboratory researches manufacturing processes and the commercialization of foaming agents, azo polymerization initiators, ultraviolet absorbing agents, rust preventive agents, electrolytes for capacitors and other items. We are engaged in extensive research and development activities including the custom synthesis of different derivatives to suit customer needs.

  • Technologies for synthesizing beta-lactam intermediates and APIs

    Technologies for synthesizing beta-lactam intermediates and APIs

    The laboratory develops formulae for different developed compounds, APIs and intermediates and verifies the scaling up of processes based on the technologies accumulated in the development of tazobactam, a beta-lactamase inhibitor, and GCLE, a key cephalosporin intermediate for pharmaceutical applications. Thus, we have a structure that enables us to fulfill customers' requests.

  • 高純度製品製造技術

    Technologies for manufacturing high-purity products

    The laboratory researches and develops technologies for manufacturing the high purity products required for metal reductants, resists, chemical mechanical polishing (CMP) slurries and other additives for semiconductors and raw materials and intermediates for pharmaceuticals. We will fulfill needs for products and the commissioned manufacturing of highly refined products, handling everything from metallic impurities to organic impurities.

Related products

Otsuka Chemical's β-lactam intermediate business provides a variety of β-lactam compounds through the application of accumulated technologies, starting with GCLE, which serves as the foundation of the business. We also offer customized synthesis of β-lactam intermediates to meet a wide range of customer needs.

  • β-lactam
  • cephalosporins
  • GCLE

CHEMCATCH is an aldehyde catcher developed to deodorize formaldehyde (a known cause of sick building syndrome) and acetaldehyde, substances that are typically emitted by new buildings and renovated spaces.

  • Aldehyde deodorant

Reactive UV absorbing RUVA-93 easily polymerizes with nyl monomers such as styrene, acryl, acrylonitrile, etc., and UV absorbing functional groups can be incorporated into the polymer chain.

  • UV absorber

Maltol and ethyl maltol are pyrone derivatives with a sweet aromatic odor similar to caramel. Since their release by Otsuka Chemical in 1977, they have been widely used by users as synthetic flavorings for food additives. In addition to synthetic flavoring agents, levulinic acid has recently been used as a hair care ingredient, and we are striving to maintain the quality of life of our customers.

  • Molding
  • Antistatic
  • Fiber

Otsuka Chemical's various aromatic compounds are a group of compounds that are expected to have a wide variety of applications in the industrial field of fine chemicals, such as raw materials for pharmaceuticals and agrochemicals, functional polymers, and polymer additives.

  • Aromatic compounds
  • Pharmaceutical raw materials
  • Agrochemical raw materials

Otsuka Chemical develops synthetic reagents for protein peptide drugs. 1-HOB (generic name: HOBt-H2O) promotes reactions during dehydration-condensation and prevents racemization of amide bonds.

  • Peptide synthesis
  • Reaction accelerator
  • Racemization inhibitor

We provide high-performance, high-purity electrolytes for capacitors based on our Nitrogen Chemistry and pharmaceutical manufacturing technologies cultivated in the hydrazine business. Our quality control by precise analysis and in-house performance evaluation facilities contribute to the high performance of electric double layer capacitors (EDLC).

  • Iinorganic
  • Inorganic salt
  • Potassium chloride

Polymer chemistry technology contributes greatly to the fields of fibers, rubber, resins, paints, or adhesives. Catalyst chemistry supports this technology from below. Otsuka Chemical sells azo polymerization initiators and has a lineup of products to meet various needs.

  • Polymerization catalyst
  • Polymerization initiator
  • AZO

Otsuka Chemical provides the SHADAN series of anticorrosive rust inhibitors for internal combustion engine cooling water manufactured using its unique optimal formulas. The SHADAN series of products are available as an anticorrosive rust inhibitors for use in general environments and also as non-freezing anticorrosive rust inhibitors for cold areas. We propose optimal products for different environments and purposes. Using even just one of our powerful FR series of detergents makes it possible to remove things that inhibit reactions such as slime, scale and rust which occurred in the everyday operation of factories' cooling towers, heat exchangers, scrubbers, screw compressors and other equipment.

  • Anti-rust
  • Anticorrosion agent
  • Washing soap

It is used as a latent curing agent for epoxies used in the fields of paints and adhesives, and as a cross-linking agent for acrylic emulsions containing ketone groups. The physical properties after curing can be controlled by the hydrazide compound used. In addition, the reducing performance of hydrazine allows it to be used as a metal reducing and chelating agent in semiconductor and other applications.

  • Epoxy resin curing agent
  • Acrylic resin crosslinking agent
  • Anti-rust

This is a blend-type blowing agentthat contributes to imparting desired functions to plastics and rubbers for which processing conditions are not compatible with conventional azodicarbonamide alone.

  • Blowing agent

Unifoam AZ Ultra is a solidifying, cohesive, dust-preventive blowing agent developed based on powder engineering and Otsuka Chemical's proprietary surface treatment technology. Unifoam AZ Ultra has the same characteristics as Unifoam AZ, while simultaneously achieving solidification and dust prevention.

  • Blowing agent

Unifoam AZ and inorganic masterbatch foaming agents suitable for injection moulding and extrusion moulding.

  • Blowing agent

UNIFOAM AZ is the generic name for organic thermal decomposition type foaming agents based on azodicarbonamide. It forms bubbles (cells) in resins, contributing to functionality and weight reduction. It is a derivative of hydrazine hydroxide and has a high level of quality through integrated production from the raw material hydrazine hydroxide.

  • Blowing agent

For inquiries
to Otsuka Chemical Co., Ltd.