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Otsuka Chemical offers triazole derivatives “1-HOB” as a coupling reagent for Protein and Peptide Synthesis. It is effective for acceleration of peptide synthesis and prevention of racemization in the formation of amide bond.
It can be used as esterification reagent. It is especially effective for racemization prevention in the peptide synthesis.
1-HOB (HOBt)
|
HBTU
|
TBTU
|
|
---|---|---|---|
Chemical formula
|
1-Hydroxybenzotriazole monohydrate |
O-(1H-Benzotriazol-1-yl)- N,N,N’,N’-tetramethyl-uronium hexafl uorophoshate |
O-(1H-Benzotriazol-1-yl)- N,N,N’,N’-tetramethyl-uronium tetrafl uoroborate |
CAS RN®
|
80029-43-2 | 94790-37-1 | 125700-67-6 |
Melting point (°C)
|
157 ~ 160 | 200 | 205 |